-Advancing structural and functional maturation of stem cell-derived cardiomyocytes remains a key challenge for applications in disease modelling, drug screening, and heart repair. So-called ‘desminopathies’ are disorders due to pathogenic variants in the DES gene and are associated with skeletal myopathies and/or various types of cardiomyopathies. Objective: Jedoch findet man molekulare Bewegungsvorgänge in allen Zelltypen. Cuvillier Göttingen (in Zusammenarbeit mit. The relationship between oxidative stress and cardiac stiffness is thought to involve modifications to the giant muscle protein titin, which in turn can determine the progression of heart disease. All rights reserved. nach Vereinbarung. : 0561 7893-0. However, testing these mechanical hypotheses on proteins in their natural environment remains inaccesible to conventional tools. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. The pathomechanisms include structural and functional changes affecting, e.g., myofiber metabolism and contractile properties. Only verified researchers can join ResearchGate and send messages to other members. We therefore tested the protective capacity of the natural autophagy inducer spermidine in animal models of aging and hypertension, which both represent major risk factors for the de... Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). 1984 - 1989 Universities of Tübingen, Munich and Göttingen, law studies. We show that under mechanical... Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent and intractable form of cardiac decompensation commonly associated with diastolic dysfunction. To expand the spectrum of bicaudal D, Drosophila, homologue 2 (BICD2) gene-related diseases, which so far includes autosomal dominant spinal muscular atrophy with lower extremity predominance 2 and hereditary spastic paraplegia due to mutations in the BICD2 gene. Göttingen. 34117 Kassel . Wolfgang König hat die Professur für Betriebswirtschaftslehre, insbesondere Wirtschaftsinformatik und Informationsmanagement an der Goethe-Universität Frankfurt inne. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. 2017 Jun;9(3):225-237. doi: 10.1007/s12551-017-0263-9. Left ventricular (LV) diastolic dysfunction is among others attributed to cardiomyocyte stiffness. To o... Aortic Stenosis (AS) is the most frequent valvulopathy in the western world. Wolfgang. Familial atrial septal defect (ASD) has previously been attributed primarily to mutations in cardiac transcription factors. Band aus Göttingen. agric. Permission is granted to copy, distribute and/or modify this document under the terms of the GNU Free Documentation License, Version 1.2 or any later version published by the Free Software Foundation; with no Invariant Sections, no Front-Cover Texts, and no Back-Cover Texts.A copy of the license is included in the section entitled GNU Free Documentation License. nat., University of Göttingen. Diese Bewegungen werden durch spezielle Struktur- und Motorproteine in den Muskelzellen ermöglicht. International space missions with ESA and NASA. Briefpostadresse 37099 Göttingen . In this study, we discovered a membrane-deforming activity of the phospholipid N -methyltransferase PmtA from the plant-pathogenic bacterium Agrobacterium tumefaciens . 1985 - 1989: ... A current and ongoing project is to link invariants from low-dimensional topology such as the Thurston norm and the Thurston polytope to generalized -torsion invariants. Methods: Acute heart failure (HF) and in particular, cardiogenic shock are associated with high morbidity and mortality. Die Universitätsmedizin Göttingen (UMG) ist Ihr Ansprechpartner für medizinische Versorgung, Lehre und Forschung auf höchstem Niveau. Aims Breeding Research Nursery Current projects: Public relations activity at Reinshof Finde 12 Profile von Wolfgang Link mit aktuellen Kontaktdaten ☎, Lebenslauf, Interessen sowie weiteren beruflichen Informationen bei XING. Reinshof, REPORT, EUFABA N. Metayer '04 V. faba for sust. Die Staatsanwaltschaft Göttingen sieht mit Blick auf die Akten über „Linksmotivierte“ keinen Anfangsverdacht bei Mitarbeitern des Göttinger Staatsschutzes. Systolic adaptations to these challenges are known but adaptations in diastolic stiffness remain unknown. E-Mail: neurologie.sekretariat(at)med.uni … Small heat shock proteins such as alphaB-crystallin (aBC) translocate under physiological or pathological stress to the titin springs. Im Profil von Wolfgang Link sind 5 Jobs angegeben. Mustapha Arbaoui, 2007: Detailed genetic analysis of faba bean, Lamiae Ghaouti, 2007: Comparison of pure line cultivars with synthetic cultivars in local breeding of faba bean (, Susanne Dieckmann geb. Due to our privacy policy, only current members can send messages to people on ResearchGate. In the original version of this article, the name of one of the authors is not correct. Aging is associated with an increased risk of cardiovascular disease and death. März 1949 geboren. We previously reported that induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) from patients with a dilated cardiomyopathy (DCM) mutation, troponin T (TnT)-R173W, display sarcomere protein mi... Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. Professor Dr. Wolfgang Link, Abteilung Zuchtmethodik der Pflanze, Carl-Sprengel-Weg 1, 37075 Göttingen Sein weiterer Weg führte Wolfgang Pauli an die Universität Göttingen, die eine langjährige Tradition als Hochburg der Mathematik aufwies. While increased passive stiffness of the myocardium is a suggested mechanism underlying diastolic dysfunction in these hearts, the contr... Reversible post-translational modifications of various cardiac proteins regulate the mechanical properties of the cardiomyocytes and thus modulate the contractile performance of the heart. This reasoning serves as entrance into our faba bean breeding research, an area that offers numerous challenges and promises due to the bean being a legume (pulse) crop, due to its seed being food and feed in temperate and semi-arid zones, due to it being a field and a garden crop and because winter and spring types exist. To date, the role of this interaction in the stress response of muscle remains poorly understood. We hypothesized that angiopoietin-2 (Angpt-2), antagonist of the endothelium-stabilizing receptor Tie2, induces a rapid loss of the eGC in human sepsis. The elasticity of muscle is principally determined by the I-band region of titin, consisting of 40-100 immunoglobulin-like (Ig) domains and Leben. Coxsackievirus B3 (CVB3)-induced myocarditis is associated with severe cardiac inflammation, which may progress to heart failure. Whereas myosin 18B (Myo18B) is known to be a critical sarcomeric protein, the function of myosin 18A (Myo18A) is unclear, although it has been implicated in cell motility and Golgi shape. Anbieter: Volksbank Kassel Göttingen eG. We hypothesized that diminished LA compliance and contractile function occur early during the development of heart failure with preserved ejection fraction (HFpEF) and impair overall cardiac performance. Recent reports suggest that mammalian embryonic coronary endothelium (CoE) develops from the sinus venosus and ventricular endocardium. In the Western countries cardiovascular disease and cancer are the leading causes of death in the ageing population. Max Planck Institute for Solar System Research. Wolfgang A. Linke Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. 234th ENMC International Workshop: Chaperone dysfunction in muscle disease Naarden, The Netherlands, 8-10 December 2017. Supplemental Table for Hamdani, Herwig, Linke, Biophys Rev. Here, we characterise the molecular stru... Background Traditionally aortic valve replacement (AVR) has been recommended immediately after the onset of heart failure (HF) symptoms. Sorry, you need to be a researcher to join ResearchGate. Mitochondrial function is critically dependent on the folding of the mitochondrial inner membrane into cristae; indeed, numerous human diseases are associated with aberrant crista morphologies. He has written four works of comparative literature and psychology of art, now considered standards of their genre. We generated a zebrafish model of an A-band TTNtv identified in 2... BACKGROUND:Truncating variants in the TTN gene (TTNtv) are common in patients with dilated cardiomyopathy (DCM) but also occur in the general population. Aims: The giant muscle protein titin is a major contributor to passive force; however, its role in active force generation is unresolved. Research Assistant, Mathematical Institute, University of Göttingen. Methods: For the first time, we report a highly controllable viral expression model based on an iPS-cell line from a healthy human donor. PmtA catalyzes the successive three-step N -... Background: We therefore investigated the influence of CX3CR1 ablation in the mode... Regulation of chemokine receptors and the corresponding chemokines in the spleen of Coxsackievirus B3-infected mice. Sie werden durch elastische Titinfilamente zusammengehalten. Left atrial (LA) compliance and contractility influence left ventricular stroke volume. With the MICOS complex, OPA1 and the F 1 F o -ATP synthase, key players of cristae bio … Rudolf-Schwander-Str. Er leitete von 1977 bis 2014 das Institut für Humangenetik der Medizinischen Fakultät der Universität Göttingen. Here, we report a large, multi-generational family (78 members) with ASD combined with a late-onset dilated cardiomyopathy and further characterize the consequences of mutant α-actin. The present work aimed to evaluate the early myocardial changes of DOXO-induced cardiotoxicity. Posttranslational modifications of titin from cardiac muscle: how, where and what for? The endothelial glycocalyx (eGC), a carbohydrate-rich layer lining the luminal surface of the endothelium, provides a first vasoprotective barrier against vascular leakage in sepsis. Winda Puspitasari, 2017: Association analyses to genetically study reproduction and seed quality features of faba bean (. So far, only a limited number of DES pathogenic variants have been identified... A detailed description of pathophysiological effects that viruses exert on their host is still challenging. The last decade has seen enormous progress in our understanding of how titin molecular elasticity is modulated in a dynamic manner to help cardiac sarcomeres adjust to the varying hemodynamic demands on the heart... Single-molecule methods using recombinant proteins have generated transformative hypotheses on how mechanical forces are generated and sensed in biological tissues. We evaluated adaptations in myocardial stiffness due to acute stretching and characterized the underlying mechanisms. 205 likes. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. Methods The Sydney Heart Bank (SHB) is one of the largest human heart tissue banks in existence. The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Es gibt 30+ Personen namens „Wolfgang Link“, die LinkedIn zum Austausch von Informationen, Ideen und Karrierechancen nutzen. A personal tribute to Johann Caspar Rüegg (1930–2018): milestones of muscle research, JACBTS Gotzmann Linke Published SupplFigure, Alterations in Titin Properties and Myocardial Fibrosis Correlate With Clinical Phenotypes in Hemodynamic Subgroups of Severe Aortic Stenosis, Diabetes-Induced Cardiomyocyte Passive Stiffening Is Caused by Impaired Insulin-Dependent Titin Modification and Can Be Modulated by Neuregulin-1, Acute stimulation of the soluble guanylate cyclase does not impact on left ventricular capacitance in normal and hypertrophied porcine hearts in vivo, P497Altered myocardial function and perfusion in a swine model of diastolic dysfunction with multiple co-morbidities, Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening, Stretch-induced compliance: A novel adaptive biological mechanism following acute cardiac load, Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease, Genetically Engineered Human Stem-Cell Derived Cardiomyocytes to Investigate the Function of Cronos Titin, Quantifying the Titin Contribution to Muscle Force Generation using a Novel Method to Specifically Cleave the Titin Springs in Situ, Supplementary Figures&Table Nat-Commun Revision Final corrected, Titin Truncation Position Determines Propensity for Dilated Cardiomyopathy, Impaired Ventricular Relaxation and Passive Stiffness in Zebrafish, Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Placenta-Derived Adherent Stromal Cells Improve Diabetes Mellitus-Associated Left Ventricular Diastolic Performance: Placenta Stromal Cells and Diastolic Relaxation, Translocation of molecular chaperones to the titin springs is common in skeletal myopathy patients and affects sarcomere function, Supplementary Figure S1 for Unger et al., Acta Neuropathol Commun. Jede Zelle besitzt ein verzweigtes Netzwerk von... Muskelkraft und -bewegung beruhen auf molekularen Prozessen in den kontraktilen Bausteinen der Muskelzellen, den Sarkomeren. Universität Göttingen. Stadt Göttingen Breslauer Straße 2 37085 Göttingen. Recent epidemiological data suggest that cancer is more frequent in patients with prevalent or incident cardiovascular disease, in particular heart failure. Kontakte Fraktion Göttinger Linke . MPS develops and builds scientific instruments that investigate solar system bodies. We explored whether intravenous (i.v.) Sehen Sie sich die Profile von Fach- und Führungskräften namens „Wolfgang Link“ auf LinkedIn an. Sehen Sie sich das Profil von Wolfgang Link im größten Business-Netzwerk der Welt an. Webseiten der Georg-August-Universität Göttingen. Using intravit... Background: Wolfgang Wucherpfennig ist Bürgermeister der Samtgemeinde Radolfshausen.Er wurde am 12. Mutations in the gene encoding for titin (TTN) are the leading known cause of familial dilated cardiomyopathy. Male New Zealand White rabbits were injected intravenously with DOXO twice weekly for 8 wk [DOXO... Titin has long been recognized as a mechanical protein in muscle cells that has a main function as a molecular spring in the contractile units, the sarcomeres. Dezember 2015 in Lenglern) war ein deutscher Arzt und Hochschullehrer. More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. Band aus Göttingen. 1. November 1940 in Ludwigshafen; † 7. The correct name should be W. A. Linke, which is shown correctly in the authorgroup section above. 1984: Dr. rer. However, this use of LVEF in clinical trials has led to oversimplification of the scientific view of a complex syndrome. Fraktion Göttinger Linke Neues Rathaus, Zi. Cooperation with IAV Hassan II (, Reproductive features and vicine content of faba bean (, Drought tolerance, marker application, faba bean (, Awadallah Abdalla Abdelmula, 1999: Genetic improvement of drought tolerance in faba beans, Hilke M. Riemer, 1999: Nmin nach Ernte: Genotypische Variation in aktiuellem Material von Ackerbohnen (, Jens Christian Vaupel, 1999: Neue CMS-Systeme für die Produktion von Minor x Major-Hybridsorten bei, Memen Surahman, 2001: Detailed genetic analysis of a wide faba bean (, Anja Kramer, 2002: Untersuchungen zum biotechnologisch unterstützten Gentransfer bei der Ackerbohne, Andi Wijaya, 2003: Towards interspecific hybridization in, Mahmoud Mohamed Zeid, 2003: Analysis of genetic diversity based on molecular markers (AFLP) and of heterosis in faba bean (. Kontakt: Telefon: 0551/400-4561 Telefax: 0551/400-4580 E-Mail: w.steinmetzer@goettingen.de Raum: 110 ZUR ÜBERSICHT. Loslösung von Myosin-Querbrücken immer wiede... Several studies have demonstrated that administration of doxorubicin (DOXO) results in cardiotoxicity, which eventually progresses to dilated cardiomyopathy. Erstes Album [wolf:gang] 25.08.18 Increased passive stiffness promotes diastolic dysfunction despite improved Ca2+ handling during left ventricular concentric hypertrophy, Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes, The Impact of cGMP-PKG Pathway Modulation on Titin Phosphorylation and Titin-Based Myocardial Passive Stiffness, Membrane Remodeling by a Bacterial Phospholipid-Methylating Enzyme, Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair, Mechanically Unfolded Titin Immunoglobulin Domains Refold Faster and More Accurately in Presence of Chaperone Alpha-B-Crystallin, A Multi-Tool Mouse Model to Study the Elasticity of Native Titin, Dietary spermidine for lowering high blood pressure, Titin-truncating variants affect heart function in disease cohorts and the general population, Cardioprotection and lifespan extension by the natural polyamine spermidine, Expanding the phenotype of BICD2 mutations toward skeletal muscle involvement, Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection FractionClinical Perspective, Developmental Basis of Cardiac Inherited Diseases470Extracardiac endothelium patterns embryonic coronary arterio-venous connections471DCM-associated RBM20-mutations lead to aberrant splicing of titin and ryanodin receptor 2 in the human myocardium472The impact of missense versus nonsense mutations in arrhythmogenic cardiomyopathy phenotype, Expression and function of dipeptidyl peptidases. Join ResearchGate to contact this researcher and connect with your scientific community. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy, and remodeling. We used hetero‐ and homozygous R349P desmin... Background Dort erfahren Sie auch die vollständige Adresse von Link Wolfgang Dr. in Göttingen-Groß Ellershausen, um Post dorthin zu schicken. Academician at Göttingen Academy of Sciences, Fellow of the International Society for Heart Research (ISHR), Franz Maximilian Groedel Research Prize of the German Cardiac Society, Heisenberg Fellowship from German Research Foundation. Research focus on the solar system with its planets and moons, comets and asteroids, and of course the Sun. Universität Göttingen. Dort liegen die Eiweiße Myosin und Aktin als Myofilamente vor. The spring region of the giant muscle protein titin contains many immunoglobulin-like (Ig) domains, which unfold and refold under low (physiological) stretch forces. Richtige Adressen und Telefonnummern finden! ll Wolfgang Link gesucht? We investigated newly generated immortalized heterozygous and homozygous R349P desmin knock‐in myoblasts in conjunction with the corresponding desminopathy mice as models for desminopathies to analyse major protein quality control processes in response to the presence of R349P mutant desmin. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Ahmed Sallam, 2014: Detailed genetic approach to improve frost tolerance of German winter faba beans. Bei Vielzellern sind die Skelettmuskeln für die Fortbewegung zuständig. Recent work suggests that the titin spring contributes to muscle contraction in a more active manner than previously thought. Link Wolfgang Dr. Möchten Sie Link Wolfgang Dr. in Göttingen-Groß Ellershausen anrufen? Aims The ability to generate patient-specific induced pluripotent stem cells (iPSCs) provides a unique opportunity for modeling heart disease in vitro. Friedhof Junkerberg Heinrich-A.-Zachariä-Bogen 12 37077 Göttingen Kontakt: Telefon: 0551/400-5210 Telefax: 0551/400-5222 E-Mail: w.giesse@goettingen.de Its mission is to provide high-quality human heart tissue for research into the molecular basis of human heart failure by working collaboratively with experts in this field. Cuvillier Verlag Göttingen. Im Wintersemester 1921/22 wurde Pauli planmässiger Assistent von Professor Max Born (Link verlässt diese Seite).Born kehrte in diesem Jahr an seine Alma Mater zurück, an der er sich bereits 1909 habilitiert hatte. Increased titin-dependent cardiomyocyte tension is a hallmark of heart failure with preserved ejection fraction (HFpEF) associated with type-2 diabetes mellitus (T2DM). in Europe; GIE féverole, Fachgespräch „Körnerleguminosen in Deutschland“ 2009 JKI Braunschweig, Markergestützte Selektion der optimalen DH-Linie, Link and Ghaouti 2012 Organic faba bean breeding, Genes count, pyramiding alleles, Summer Seminar 2014, Schnell Zweisatz-Gitter-Anlage Versuchsanlage, 1999 Geiger Populationsgenetik + Pflanzenzüchtung, Directories of courses and people (UniVZ), DFG Projekt: "Molecular and quantitative-genetic analysis of seed size in faba bean (, Abo-Vici: "Breeding and agronomy of novel, low-vicine faba beans and adoption as domestic protein feed", Faba bean: Genetic analysis of the Ascochyta-resistance of faba bean (, Faba bean: genetic increase and stabilization of grain yield via optimum exploitation of heterosis; Analysis of pollination and pollinators, Breeding research on the mixed cropping of faba bean and wheat, Regional chicken races, regional protein feed ("PorReE"), Population structure und breeding method in case of partial allogamy, Research on faba bean drought and weed tolerance in Morocco.
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